Workpackages

Project workpackages

 

 

Collaborative working

The Nano ChOp research project brings together partners with complementary expertise required  to develop a metrology framework to support the physical, chemical and optical characterisation of nanomaterials in biological systems.

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Work Package 1

System selection and development This work package provides the basis for research carried out in the other work packages by: Selecting suitable and representative, particulate nanomaterials Identifying and developing appropriate dispersion protocols in aqueous media, serum and cell media Preparing and distributing homogeneous and stable suspensions of the selected nanomaterials which will be further characterised …

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Work Package 2

Validation of methods for the physical characterisation of nano-objects The aim of this work package is to validate measurement techniques for the characterisation of physical properties of particulate nanomaterials, especially dimensional properties like size and size distribution, but also surface charge, agglomeration state and concentration. This workpackage is divided into several tasks: Techniques to determine …

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Work Package 3

Characterisation of fluorescent particles The aim of this workpackage is to establish and validate measurement techniques for the traceable optical characterisation of fluorescent nanomaterials, especially for the key fluorometric parameter fluorescence quantum yield. In addition, for selected materials, also other spectroscopic methods for the determination of parameters controlling the signaling behavior of fluorescent nanoparticles will …

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Work Package 4

Validated methods for simultaneous physical and chemical characterisation of nanomaterials in biological systems This work package aims to provide traceable simultaneous measurements for the determination of size, total element concentration and size-related elemental speciation of inorganic nanoparticles (as defined in WP1) in biological samples such as cell media and cell extracts. This will be achieved …

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Work Package 5

Uncertainties in Biotechnology Assays using fluorescent nanoparticles The aim of this work package is to investigate the barriers to the use of fluorescent nanoparticles in biotechnology assays such as immunoassays. Immunoassays are frequently used in biotechnology, clinical and research laboratories to measure the concentrations of biological analytes, often at very low (nanomolar) concentrations. Compared to …

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Work Package 6

Creating Impact The primary aim of this project is to develop and validate technologies for the physical, chemical and optical characterisation of nanomaterials in biological matrices. Direct impact will result from the establishment of this new measurement capability within the NMIs themselves. Outside of the immediate consortium, wider target beneficiaries for the project are: Nanobiotechnology …

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Work Package 7

Joint Research Project Management and Coordination LGC will act as project co-ordinator, ensuring that the project is effectively completed to time and budget. Management and reporting of the project will be in accordance with EMRP guidelines, with the co-ordinator having overall responsibility for: Overall responsibility for the technical direction of the project, pro-actively assessing progress …

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